A Molecular Perspective on Sirtuin Activity
نویسندگان
چکیده
منابع مشابه
a head parameter survey on mazandarani dialect and its effect(s) on learning english from ca perspective (on the basis of x-bar syntax)1
there has been a gradual shift of focus from the study of rule systems, which have increasingly been regarded as impoverished, … to the study of systems of principles, which appear to occupy a much more central position in determining the character and variety of possible human languages. there is a set of absolute universals, notions and principles existing in ug which do not vary from one ...
15 صفحه اولA Molecular Mechanism for Direct Sirtuin Activation by Resveratrol
Sirtuins are protein deacetylases regulating metabolism, stress responses, and aging processes, and they were suggested to mediate the lifespan extending effect of a low calorie diet. Sirtuin activation by the polyphenol resveratrol can mimic such lifespan extending effects and alleviate metabolic diseases. The mechanism of Sirtuin stimulation is unknown, hindering the development of improved a...
متن کاملSirtuin 4 Is a Lipoamidase Regulating Pyruvate Dehydrogenase Complex Activity
Sirtuins (SIRTs) are critical enzymes that govern genome regulation, metabolism, and aging. Despite conserved deacetylase domains, mitochondrial SIRT4 and SIRT5 have little to no deacetylase activity, and a robust catalytic activity for SIRT4 has been elusive. Here, we establish SIRT4 as a cellular lipoamidase that regulates the pyruvate dehydrogenase complex (PDH). Importantly, SIRT4 catalytic...
متن کاملInsight the C-Site Pocket Conformational Changes Responsible for Sirtuin 2 Activity Using Molecular Dynamics Simulations
Sirtuin belongs to a family of typical histone deacetylase which regulates the fundamental cellular biological processes including gene expression, genome stability, mitosis, nutrient metabolism, aging, mitochondrial function, and cell motility. Michael et. al. reported that B-site mutation (Q167A and H187A) decreased the SIRT2 activity but still the structural changes were not reported. Hence,...
متن کاملa critical discourse analysis on gender representation in the iranian english books 2, 3 and top notch 2a, 2b a critical discourse analysis perspective
هدف از انجام تحقیق حاضر، مطالعه و بررسی نقش زنان و مردان در دو مجموعه از کتابهای درسی انگلیسی در قالب تحلیل گفتمان انتقادی و همچنین، بررسی و آشکار ساختن اصول ایدوئولوژیکی مربوط به نقش زنان و مردان در این کتابها است. این دو مجموعه کتاب عبارتنداز: کتابهای انگلیسی سال دوم و سوم دبیرستانی ایران و کتابهای تاپ ناچ 2آ و 2ب. برای انجام این منظور، مدل تحلیل گفتمان انتقادی فرکلاف مورد استفاده قرار گرفته ...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21228609